GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs11782652 | 1 | rs78740005 | chr8:82659306 | CHMP4C | chr8:82644688-82671746:+ | -1.01 | -4.77 | 4.27E-6 | Epithelial ovarian cancer;Ovarian cancer |
| UCEC | cis | rs1577917 | 1 | rs791856 | chr6:86681841 | SNHG5 | chr6:86386726-86388451:- | 0.46 | 5.88 | 2.51E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs950169 | 1 | rs79318564 | chr15:84786150 | LOC388152 | chr15:84867600-84898920:- | -0.48 | -5.07 | 1.14E-6 | Schizophrenia |
| UCEC | cis | rs9815354 | 1 | rs79548696 | chr3:41803385 | ULK4 | chr3:41288091-42003660:- | 0.51 | 6.04 | 1.16E-8 | Diastolic blood pressure |
| UCEC | cis | rs60843830 | 1 | rs79716074 | chr2:277003 | SH3YL1 | chr2:218138-264810:- | -0.5 | -6.77 | 2.7E-10 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs8010715 | 1 | rs8010715 | chr14:24609147 | FAM158A | chr14:24608175-24610797:- | -0.48 | -8.54 | 1.28E-14 | IgG glycosylation |
| UCEC | cis | rs2028299 | 1 | rs8031576 | chr15:90380214 | AP3S2 | chr15:90373832-90456222:- | -0.44 | -4.46 | 1.59E-5 | Type 2 diabetes |
| UCEC | cis | rs703842 | 1 | rs8181644 | chr12:58173466 | TSFM | chr12:58176536-58191367:+ | -0.45 | -4.86 | 2.91E-6 | Multiple sclerosis |
| UCEC | cis | rs823128 | 1 | rs823128 | chr1:205713378 | PM20D1 | chr1:205797154-205819245:- | -0.62 | -4.61 | 8.55E-6 | Parkinson's disease |
| UCEC | cis | rs10461617 | 1 | rs832551 | chr5:56180112 | C5orf35 | chr5:56205103-56213010:+ | 0.6 | 6.24 | 4.09E-9 | Type 2 diabetes |
| UCEC | cis | rs10461617 | 1 | rs832553 | chr5:56114786 | C5orf35 | chr5:56205103-56213010:+ | 0.56 | 6.25 | 3.95E-9 | Type 2 diabetes |
| UCEC | cis | rs10461617 | 1 | rs832554 | chr5:56115036 | C5orf35 | chr5:56205103-56213010:+ | 0.53 | 5.58 | 1.05E-7 | Type 2 diabetes |
| UCEC | cis | rs10461617 | 1 | rs832565 | chr5:56150803 | C5orf35 | chr5:56205103-56213010:+ | 0.62 | 6.79 | 2.38E-10 | Type 2 diabetes |
| UCEC | cis | rs10461617 | 1 | rs832568 | chr5:56153776 | C5orf35 | chr5:56205103-56213010:+ | 0.62 | 6.79 | 2.38E-10 | Type 2 diabetes |
| UCEC | cis | rs10461617 | 1 | rs832569 | chr5:56154584 | C5orf35 | chr5:56205103-56213010:+ | 0.62 | 6.79 | 2.38E-10 | Type 2 diabetes |